I have a story which could fit nearly any genre and still be engaging, and often times the back cover synopsis likes to brag about multiple elements, like "It has suspense, drama, rib-splitting humor, and wild action!" all together. Let's say you have all that, and to pull it off you are weaving together many plot arcs. Family drama, government conspiracies, hidden agendas, tragic losses, blazing gunfights, comic mishaps, etc. We'll call it "life, completely told."
I would assume this needs to be kept on track by not also shifting character focus around, but that is a guess honestly. Is there a golden rule for making engaging stories with complex interwoven arcs—that remain engaging to people who aren't chess masters? (That last bit is in there because I am frequently told to dumb things down)