I don't know.
I have an idea for a story set during the Sioux Wars, in which a family related by adoption are involved in conflicts from the Spirit Lake Massacre in 1857 to the Great Sioux War in 1876.
Naturally a lot of historic persons will be in the story, and a number of the fictional characters will be based upon historical persons that persons knowledgeable about the Sioux wars will recognize.
And I could write several paragraphs describing the relationships between fictional characters in my story and historic persons, including many who were killed.
George MacDonald Fraser wrote a series of novels supposedly to be the memoirs of the fictional Harry Paget Flashman, a rogue who is involved in many 19th century military conflicts, including many bloody battles where hundreds or thousands are killed.
Even though Flashman is a coward, he manages to get a reputation as a military hero. At the Battle of Balaclava Flashman is forced by circumstances to participate against his will in the 3 main British actions, the Thin Red Line, the Charge of the Heavy Brigade, and the Charge of the Light Brigade.
When Flashman takes part in the disastrous retreat from Kabul in 1842, there is a brief scene with Flashman, a fellow officer named Vincent, and a little Indian girl. Vince was a real officer who survived, and mentioned that scene (without Flashman of course) in his book about the war.
In one book Flashman escapes from the battle of Isandhlwana on January 22, 1879, in which thousands on both sides were killed.
Victorian novelist H. Rider Haggard wrote a number of novels about adventurer Allan Quatermain, who was more or less inspired will life adventurers like Frederick Selous and Frederick Russell Burnham.
In Finished (1917) Allan Quartermain is one of the few white survivors of Isandhlwana.
Haggard also wrote The Witch's Head (1885) in which the protagonist also is one of the few white survivors of Isandhlwana. He joins a unit of mounted colonial volunteers that is wiped out in the battle. The commander of the unit and his 14-year-old son are both killed. Where did Haggard get the idea for a father taking his 14-year-old son into battle and them being killed? That happened at the Battle of Hlobane 28 March 1879. And Haggard was personally acquainted with that family.
So he wrote about fictional characters being killed based on the real deaths of people he knew.
A lot of movies are based on on historical natural disasters.