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Is mixing cultures in a fantasy book frowned upon?

everyone. I am writing a fantasy/steampunk/horror novel, and I'm wondering if mixing different cultures is frowned upon. Specifically, my novel's setting is a mix of Italy, Ancient Rome, and Transalvania/Romania. The setting itself is based off of 19th-century Italy, but the names, goverment structure, and empire resemble Ancient Rome. However, there are vampire-like creatures (who can also control the elements), and the other language occasionally spoken (mostly for nicknames and cursing) is Romanian. The creatures are also very diverse: there are sirens, bean nighe's, headlsss horsemen (they're kind of like ringwraiths), and gods. Is mixing cultures okay, and if so, do you have any tips? Thanks in advance.