It depends on your skill level, and what you are trying to do.
Maybe it will be a bit easier to take an example from a bit farther in the past so as to have a little less emotional baggage attached. Consider the ancient Romans, round-about the first century AD. They did lots of things that we today find horrible. Slaves, gladiator contests to the death, animal fighting from roosters fighting roosters up to tigers fighting bears. And some other things that I won't describe here, even in side-ways terms. It is the usual opinion these days that such things are completely horrible and unacceptable.
But consider it from the point of view of a citizen of Rome at the time. Consider a Roman mother trying to teach her children how to behave in the culture of the time. Say a well-to-do Roman, somebody with enough money for a house and some land. If this person's parents were to have trained him from birth to hate slavery, then he would never buy a slave. He would be at a distinct disadvantage in his culture.
So, in a sense, his parents would have been bad parents to teach him that way. They would have been severely poorly preparing him for life. Maybe even condemning him to relative poverty. Maybe, if things got bad enough, he might even be enslaved himself.
The culture around us is a powerful force. Portraying it as such is a challenge. Not portraying it in terms of cliché and surface appearances is a bigger challenge.
So, portraying the NAZIs as half-human half-animal is potentially going to get in the way of telling that story. You are going to have to work very hard to portray the experience of this character through that visage. It's a fairytale surface thing, the big-bad-wolf image. You need to show the character, and in particular the internal reasons for what he does, not just his animal snout. You want to avoid "look at the evil animal."
Or, to put it another way: The thing that made the NAZIs evil wasn't the fact that some of their uniform insignia had skulls on them.
However: If you manage it, you could well have a remarkable work. As an example, consider Maus. This is a graphic novel about NAZI Germany. Jews are depicted as mice, NAZIs as cats. But it manages not to be cliché. And even though it is a cartoon, it manages not to be cartoonish. The phrase is "subverts expectations."