Let's suppose, for the sake of argument,* that there are no legal issues and you can just do whatever you want. It's still not a good idea.
If you use a real video game, there will inevitably be fans of this game. Probably a lot of fans, unless you pick an obscure game (at which point, I have to ask, why bother?). Those fans are not going to be happy if any aspect of the game is misrepresented, simplified, or taken out of context. At a minimum, it will take them out of the story. This may be effective, in the context of the horror you are trying to write, but it has to be obvious that you're doing it deliberately, and so as a consequence, you will need to do a lot of research to get all the original details right (so that you can get them believably wrong, and have your protagonist notice it at the appropriate juncture). Some of those details may be inconvenient for the story you want to write, and the research itself will occupy time that you could otherwise spend on writing.
On the other hand, there will also be non-fans, people who've never played the original. Unless we're talking about one of the most popular franchises in the world (e.g. Mario), you will need to introduce those people to the game, and then you'll have to convince them that "something is wrong." The latter entails explaining how the game is "supposed to" play in the first place, so that the reader can recognize the discrepancies. You would have to do that with an original game, too, but the point is that using a real game doesn't make this task any easier, and in fact may make it harder, because as discussed above, the fans won't like it if you simplify things.
Instead, I believe you're probably better off making up a video game, perhaps making it superficially resemble a real game, but with a clearly fictitious title. This will give you several advantages:
- Legal clarity that you're not infringing anyone's rights.
- You can alter the game to exactly fit your intended plot, symbolism, etc.
- A fictitious game will most likely be simpler and easier for readers to understand. This is to your advantage, as some of your readers may have never played the original.
- You can freely make use of the characters and story setting of the game without having to worry about getting permission. This lets you go into much greater detail about the contents of the game, if doing so is helpful to your plot.
- If your book is a wild success, you can write a spinoff e.g. novelizing the events of the game, or even license the game rights out to a developer and have someone make it for real.
* There is a colorable legal argument that what you describe is nominative use, and not covered by trademark law at all. A "this is a work of fiction, not affiliated with brand X" disclaimer would probably help, but that is getting into the realm of legal advice. Talk to your agent/publisher and see what they think, if you have one. You can also try writing to the developer of the game, who may or may not be willing to give you permission depending on who they are and how you plan to represent their product.