Dmann's answer has already done a good job addressing some general points about writing genre fiction and getting test readers, and nick's answer covered changing aesthetics. But I wanted to mention one aspect of superhero fiction specifically (as well as fantasy hard magic systems) that can help avoid drawing undesired comparisons with prior art. Namely: don't underestimate the freedom you get by making powers weird.
If I tell you I have a character who can climb walls and trap opponents with spider webs—you are going to think "Spider-Man", even though Spider-Man has a bunch of other powers besides those. But what if I tell you I have a character who can make building materials sticky, so he can climb walls by making the wall adhesive, and throw bricks at his enemies to trap them? No one is going to think that character is Spider-Man.
If I tell you I have a character who can fly anywhere on Earth in seconds, is immune to bullets, and can punch you hard enough to turn you into red mist—you are going to think "Superman," even though Flying Brick is an entire trope. But what if I tell you I have a character who hovers constantly in midair and can teleport from place to place instantly, but can only move by teleporting and never touches the ground because any solid matter that touches his skin is instantly teleported into the Earth's core? Well, he can get anywhere on Earth in seconds, he's immune to bullets, and he can kill you with a touch… but no one is going to think "Superman." (This description also suggests some dramatically-convenient weaknesses that arise more naturally than Superman's kryptonite. He's immune to solid objects, but what about liquids/gases/plasma?)
Those are just some examples I made up on the spot. Rather than creating characters that have the same set of powers as some character you are already familiar with, consider whether it would work better in the context of your story to create a character whose powers fill a similar functional role to another character you are familiar with but that work very differently in the details.
If you are short on ideas for "weird powers," it might help to spend some time surfing around on sites such as r/whowouldwin and r/respectthreads, and to read some works that are known for off-the-wall superpowers such as Worm or JJBA. Or just take a handful of powers from DC and Marvel and try to figure out ways to twist them.