Originally I asked this question: What is a "methodology" I can I use/follow to determine the ideal set of protagonists for my story?, but found that it was too vague.
Specifically, I'm trying to decide if my story would benefit from switching between two main characters in first-person or if I should stick with a single first-person narrative or use third-person omniscient.
Things to consider in addition to the general question: Both characters have extremely different background knowledge(s) and outlooks on things. They each have a unique voice. They will primarily spend their time together, but will have segments apart from each other. At first, they will have the same plotline, but later will have complimenting roles and goals and such.