All the technical considerations really do come back to the fact that someone has to stage it. So from that point of view, you'd want to put yourself in the place of those choosing a play to do. Of course, what they are looking for could vary largely. Here are a couple of possibilities:
High School Play - Lots of high schools do plays, so that makes up a relatively large market. Some schools stick strictly to well-known classics, but others take some chances. They'll be looking for maximum participation, so they'll want a large cast. Depending on the director and the community, they'll probably something that would be rated G, PG or PG-13 if it was an American movie. They probably won't have much budget, so they'll need simple, minimalist sets and few or no scene changes. This is why so many high schools continue to do "Our Town." Community theater presentations, with volunteer actors, will be looking for pretty much the same range of considerations.
Indie Production - This is a low-budget, but professional production. Since they are paying their actors, they'll want a small cast --three to five characters --and more challenging, meaty, and adult material. Given the low budget, they'll also need simple sets.
Blockbuster Musical - Since this is a big budget spectacle, you'll want to pull out all the stops. Full cast of union actors, full orchestra, multiple fancy sets and big pyrotechnic gimmicks. Although, if you can find creative ways to do any of that on the cheap, you'll do even better.
Actor Showcase - This is a piece that a veteran actor can take on the road. It shows off all of his or her skills (he sings, he dances, she makes people laugh, she moves them to tears) but it doesn't require much in the way of other actors or a set. So, it's basically a set of monologues.
You may have noticed that pretty much everyone is going to be looking for a simple set because sets are expensive. There's a philosophy of theater, going back to the ancient Greeks, that plays should respect the "three unities" (one action, one place, one time), which of course, does make the sets simpler. More modern plays often get around this with creativity. Scenery is visibly carried/portrayed by actors in The Lion King. Most of Death of a Salesman takes place in the main character's head. The sets in Man of La Mancha are explicitly presented as hastily improvised and makeshift within the play's narrative.
These aren't artistic limitations they're technical ones, but they are pretty decisive. I think you'll find nearly all the modern plays you've ever seen fit in one of these boxes. The artistic creativity comes in finding out cheats or ways around these limits (which, after all, is pretty much what Shakespeare did too).