The modern world has few true mysteries, among them the fate of the Roanoke colonists and the crew of the Mary Celeste but do such happenings have a place in futuristic settings?

In settings with locally instantaneous communication and ubiquitous forensics using techniques we'd recognise but with equipment of far greater sensitivity is there any room left for not being able to explain odd happenings?

I'd like to have a setting which is technologically advanced where the "every day life" can be explained to a degree that almost makes life boring but in which a few paradoxical situations still have the scientists throw up their hands in puzzled disbelief once in a while. How can this be achieved without creating a visible paradox that is damaging to suspension of disbelief?

The modern world has few true mysteries, among them the fate of the Roanoke colonists and the crew of the Mary Celeste but do such happenings have a place in futuristic settings?

In settings with locally instantaneous communication and ubiquitous forensics using techniques we'd recognise but with equipment of far greater sensitivity is there any room left for not being able to explain odd happenings?

I'd like to have a setting which is technologically advanced where "every day life" can be explained to a degree that almost makes life boring but in which a few paradoxical situations still have the scientists throw up their hands in puzzled disbelief once in a while. How can this be achieved without creating a visible paradox that is damaging to suspension of disbelief?